باروری و ناباروری ایران

Methodological limitations in studying the association between the use of fertility drugs and cancer include the inherent increased risk

of cancer in women who never conceive, the low incidence of most of these cancers, and that the age of diagnosis of cancer typically is

many years after fertility drug use. Based on available data, there does not appear to be a meaningful increased risk of invasive ovarian

cancer, breast cancer, or endometrial cancer following the use of fertility drugs. Several studies have shown a small increased risk of

borderline ovarian tumors; however, there is insufficient consistent evidence that a particular fertility drug increases the risk of borderline

ovarian tumors, and any absolute risk is small. Given the available literature, patients should be counseled that infertile women may

be at an increased risk of invasive ovarian, endometrial, and breast cancer; however, use of fertility drugs does not appear to increase

this risk. (Fertil Steril
2016;106:1617–26. 2016 by American Society for Reproductive Medicine.)