Since the effects of gender-affirming
therapy on fertility are unknown, multiple
medical societies endorse the preservation of
fertility in persons who identify as transgender.1-3
In transgender male adolescents (with a natal
female sex), the pubertal transition to female sex
can lead to gender dysphoria, which is often
treated with gonadotropin-releasing hormone
(GnRH) agonists to prevent pubertal development.
This presents a unique clinical challenge
of providing effective preservation of fertility without
exacerbating gender dysphoria and undesired
pubertal development if GnRH agonists are discontinued.
In addition, the practicality of cryopreservation
of oocytes is uncertain in patients
who have not completed puberty. Here, we describe
our multidisciplinary approach to cryopreservation
of oocytes in a transgender male
adolescent who was receiving GnRH agonist
therapy and who wished to have genetically related
children.